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- Preclinical Efficacy and Safety of a Human Embryonic Stem . . .
cGMP manufacturing of MSK-DA01 cells, which were differentiated from hES cells (WA09 FRS at passage 48, XX), was performed by members of the SKI Stem Cell Research Facility (SCRF) at the GMP facility named Cell Therapy and Cell Engineering Facility (CTCEF) at MSKCC, directed by Dr Isabelle Rivière
- Phase I trial of hES cell-derived dopaminergic neurons for . . .
The same cryopreserved cell product tested here, named bemdaneprocel (formerly MSK-DA01), was then used in the clinical trial We conducted a first-in-human, multisite, open-label phase I trial
- Preclinical Efficacy and Safety of a Human . . . - Cell Press
Building on those results, we report here the large-scale manufacture of cryopre-served clinical-grade cells, named MSK-DA01 We also present the design and results of toxicity, biodistribution, tumorigenicity, and efficacy studies in rodents
- Clinical Trial for Parkinson’s Disease - Cell Press
WA09 cells, the source of DA neurons used for transplantation, are described in detail, including normal karyotype, >90% Oct4+ SSEA4+ cells (test result = 96 6%) Regarding the quality control of the final product (MSK-DA01 cells), Piao et al used a flow cytometry assay and described FOXA2+ cells (DA progenitor cells) >85% (test result = 90
- Embryonic stem cells go from bench to bedside for Parkinson’s . . .
Working with hESC line WA09 (originally generated at the University of Wisconsin), Dr Tabar and her team performed four large-scale manufacturing and cryopreservation rounds to generate clinical-grade progenitors, named MSK-DA01
- WA09 - WiCell
Thomson, J A ``Embryonic Stem Cell Lines Derived from Human Blastocysts `` Science 282 5391 (1998): 1145-147 Have you received this cell line previously? Yes No Why we ask Virus testing was completed for this cell line using this lot
- Cell Therapy, DA01, Cleared for 1st Trial in Advanced . . .
Developed by BlueRock, a wholly owned subsidiary of Bayer, in collaboration with Memorial Sloan Kettering Cancer Center (MSK), DA01 is made up of dopamine-producing neurons derived from human embryonic stem cells (ESCs)
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